BDBM50116766 (-)-Pramipexole::(6S)-N(6)-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine::2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N(sup 6)-propyl-, (S)-::CHEMBL301265::PRAMIPEXOLE::cid_119570

SMILES CCCN[C@H]1CCc2nc(N)sc2C1

InChI Key InChIKey=FASDKYOPVNHBLU-ZETCQYMHSA-N

Data  66 KI  9 IC50  7 Kd  22 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50116766   

TargetD(4) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataKi:  8.10nMAssay Description:High inhibition constant against [3H]-spiperone binding to human Dopamine receptor D4.4 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(4) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataKi:  8.10nMAssay Description:High binding affinity towards human dopamine receptor 4.4 expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(4) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataKi:  8.5nMAssay Description:Binding affinity of compound measured using [3H]-spiperone for the cloned human Dopamine receptor D3 (high/low affinity is given as 25/1600)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(4) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]-N-methylspiperone from recombinant human D4 receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(4) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataKi:  130nMAssay Description:Low binding affinity towards human dopamine receptor 4.4 expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(4) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataKi:  130nMAssay Description:Low inhibition constant against [3H]-spiperone binding to human Dopamine receptor D4.4 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(4) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataEC50:  15nMAssay Description:Effective concentration required for agonistic activity against human D4.2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(4) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataEC50:  15nMAssay Description:Effective concentration to stimulate human Dopamine receptor D4.2 mediated [3H]-thymidine incorporation into growing cells using mitogenesis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank